TAXUS VI 2-year follow-up: randomized comparison of polymer-based paclitaxel-eluting with bare metal stents for treatment of long, complex lesions
Identifieur interne : 001297 ( Main/Exploration ); précédent : 001296; suivant : 001298TAXUS VI 2-year follow-up: randomized comparison of polymer-based paclitaxel-eluting with bare metal stents for treatment of long, complex lesions
Auteurs : Eberhard Grube [Allemagne] ; Keith D. Dawkins [Royaume-Uni] ; Giulio Guagliumi [Italie] ; Adrian P. Banning [Royaume-Uni] ; Krzysztof Zmudka [Pologne] ; Antonio Colombo [Italie] ; Leif Thuesen [Danemark] ; Karl Hauptman [Allemagne] ; Jean Marco [France] ; William Wijns [Belgique] ; Jeffrey J. Popma [États-Unis] ; Lutz Buellesfeld [Allemagne] ; Joerg Koglin [États-Unis] ; Mary E. Russell [États-Unis]Source :
- European Heart Journal [ 0195-668X ] ; 2007-11.
Abstract
Aims Drug-eluting stents (DESs) have shown to be effective in reducing in-stent restenosis, although data relating to long-term experience in treating more complex lesion subsets are limited. In order to assess the long-term safety and clinical efficacy of the polymer-based moderate release (MR) paclitaxel-eluting TAXUS MR stent in treatment of complex lesion subsets, we evaluated the 2-year follow-up of TAXUS VI. Method and results TAXUS VI was a randomized multi-centre study enrolling 446 patients with complex lesions, including small vessels in 28 of patients and a mean lesion length of 20.6 mm. At 9-month follow-up, the use of the TAXUS MR stent was highly effective, resulting in a significant 53 reduction of the target vessel revascularization (TVR) rate (primary endpoint) from 19.4 in the control group to 9.1 in the TAXUS group (P 0.0027). Clinical follow-up at 2 years post-stenting was available in 98.6 of the TAXUS group and 95.6 of the control group. The incidence of major adverse cardiac event at 1- and 2-year follow-up was 16.4 and 21.3 in the TAXUS group when compared with 22.5 and 25.1 in the control group, respectively. A significant difference in TVR was maintained at 2-year follow-up (TAXUS 13.9; control 21.9; P 0.0335). The cumulative 1- and 2-year survival rates free from TVR were, respectively, 91.7 and 90.3 in the TAXUS group vs. 80.0 and 79.0 in the control group (log-rank P < 0.001). The number of patients required to be treated with a TAXUS stent to prevent one re-percutaneous coronary intervention at 2 years was 12.5. Conclusion Treatment of complex coronary lesions with the polymer-based MR paclitaxel-eluting TAXUS MR stent is associated with a sustained clinical benefit and low rates of TVR up to 2 years after device implantation.
Url:
DOI: 10.1093/eurheartj/ehm424
Affiliations:
- Allemagne, Belgique, Danemark, France, Italie, Pologne, Royaume-Uni, États-Unis
- Angleterre, Massachusetts, Midi-Pyrénées, Occitanie (région administrative), Oxfordshire
- Boston, Oxford, Toulouse
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Hospital, Aalst</wicri:regionArea><wicri:noRegion>Aalst</wicri:noRegion></affiliation></author><author><name sortKey="Popma, Jeffrey J" sort="Popma, Jeffrey J" uniqKey="Popma J" first="Jeffrey J." last="Popma">Jeffrey J. 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Russell</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Boston Scientific Corporation, Natick</wicri:regionArea><wicri:noRegion>Natick</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">European Heart Journal</title><idno type="ISSN">0195-668X</idno><idno type="eISSN">1522-9645</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2007-11">2007-11</date><biblScope unit="volume">28</biblScope><biblScope unit="issue">21</biblScope><biblScope unit="page" from="2578">2578</biblScope><biblScope unit="page" to="2582">2582</biblScope></imprint><idno type="ISSN">0195-668X</idno></series><idno type="istex">43F76346907EFD17DF24503171D45668BBDA6ED6</idno><idno type="DOI">10.1093/eurheartj/ehm424</idno><idno type="ArticleID">ehm424</idno><idno type="Related-article-href">10.1093/eurheartj/ehl195</idno><idno type="related-article-ID">RA1</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0195-668X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Aims Drug-eluting stents (DESs) have shown to be effective in reducing in-stent restenosis, although data relating to long-term experience in treating more complex lesion subsets are limited. In order to assess the long-term safety and clinical efficacy of the polymer-based moderate release (MR) paclitaxel-eluting TAXUS MR stent in treatment of complex lesion subsets, we evaluated the 2-year follow-up of TAXUS VI. Method and results TAXUS VI was a randomized multi-centre study enrolling 446 patients with complex lesions, including small vessels in 28 of patients and a mean lesion length of 20.6 mm. At 9-month follow-up, the use of the TAXUS MR stent was highly effective, resulting in a significant 53 reduction of the target vessel revascularization (TVR) rate (primary endpoint) from 19.4 in the control group to 9.1 in the TAXUS group (P 0.0027). Clinical follow-up at 2 years post-stenting was available in 98.6 of the TAXUS group and 95.6 of the control group. The incidence of major adverse cardiac event at 1- and 2-year follow-up was 16.4 and 21.3 in the TAXUS group when compared with 22.5 and 25.1 in the control group, respectively. A significant difference in TVR was maintained at 2-year follow-up (TAXUS 13.9; control 21.9; P 0.0335). The cumulative 1- and 2-year survival rates free from TVR were, respectively, 91.7 and 90.3 in the TAXUS group vs. 80.0 and 79.0 in the control group (log-rank P < 0.001). The number of patients required to be treated with a TAXUS stent to prevent one re-percutaneous coronary intervention at 2 years was 12.5. Conclusion Treatment of complex coronary lesions with the polymer-based MR paclitaxel-eluting TAXUS MR stent is associated with a sustained clinical benefit and low rates of TVR up to 2 years after device implantation.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Belgique</li><li>Danemark</li><li>France</li><li>Italie</li><li>Pologne</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Massachusetts</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li><li>Oxfordshire</li></region><settlement><li>Boston</li><li>Oxford</li><li>Toulouse</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Grube, Eberhard" sort="Grube, Eberhard" uniqKey="Grube E" first="Eberhard" last="Grube">Eberhard Grube</name></noRegion><name sortKey="Buellesfeld, Lutz" sort="Buellesfeld, Lutz" uniqKey="Buellesfeld L" first="Lutz" last="Buellesfeld">Lutz Buellesfeld</name><name sortKey="Hauptman, Karl" sort="Hauptman, Karl" uniqKey="Hauptman K" first="Karl" last="Hauptman">Karl Hauptman</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Dawkins, Keith D" sort="Dawkins, Keith D" uniqKey="Dawkins K" first="Keith D." last="Dawkins">Keith D. Dawkins</name></noRegion><name sortKey="Banning, Adrian P" sort="Banning, Adrian P" uniqKey="Banning A" first="Adrian P." last="Banning">Adrian P. Banning</name></country><country name="Italie"><noRegion><name sortKey="Guagliumi, Giulio" sort="Guagliumi, Giulio" uniqKey="Guagliumi G" first="Giulio" last="Guagliumi">Giulio Guagliumi</name></noRegion><name sortKey="Colombo, Antonio" sort="Colombo, Antonio" uniqKey="Colombo A" first="Antonio" last="Colombo">Antonio Colombo</name></country><country name="Pologne"><noRegion><name sortKey="Zmudka, Krzysztof" sort="Zmudka, Krzysztof" uniqKey="Zmudka K" first="Krzysztof" last="Zmudka">Krzysztof Zmudka</name></noRegion></country><country name="Danemark"><noRegion><name sortKey="Thuesen, Leif" sort="Thuesen, Leif" uniqKey="Thuesen L" first="Leif" last="Thuesen">Leif Thuesen</name></noRegion></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Marco, Jean" sort="Marco, Jean" uniqKey="Marco J" first="Jean" last="Marco">Jean Marco</name></region></country><country name="Belgique"><noRegion><name sortKey="Wijns, William" sort="Wijns, William" uniqKey="Wijns W" first="William" last="Wijns">William Wijns</name></noRegion></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Popma, Jeffrey J" sort="Popma, Jeffrey J" uniqKey="Popma J" first="Jeffrey J." last="Popma">Jeffrey J. Popma</name></region><name sortKey="Koglin, Joerg" sort="Koglin, Joerg" uniqKey="Koglin J" first="Joerg" last="Koglin">Joerg Koglin</name><name sortKey="Russell, Mary E" sort="Russell, Mary E" uniqKey="Russell M" first="Mary E." last="Russell">Mary E. Russell</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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